High Quality Succinic Acid CAS 110-15-6

1). Store in a cool, ventilated warehouse. Keep away from fire and heat source. It should be stored separately from oxidizing agents, reducing agents and alkalis, and should never be mixed.
2). Equipped with appropriate varieties and quantities of fire fighting equipment. The storage area should be equipped with suitable materials to shelter the leakage.

1). Mainly used in the production of derivatives such as succinic anhydride and succinic acid esters, used as raw materials for paints, dyes, adhesives, drugs, etc.
2). Used as chemical reagent and chromatographic reagent, also used in the preparation of buffer.
3). Succinic acid is the intermediate of fungicide myclobutanil and plant growth regulator butyrylhydrazine.

Reacts with bases. Reactions such as esterification and reduction can also occur. Dehydrated by heat to form succinic anhydride. Nucleophilic substitution reaction can occur, the hydroxyl group is replaced by halogen atoms, amine compounds, acyl groups, etc.

1. Antibacterial effect of succinic acid in 2mg/ml concentration of Staphylococcus aureus, Katharococcus, as well as typhoid fever, green pus, metamorphosis, dysentery bacillus has an inhibitory effect.
2. Central inhibitory effect of rats, mice, guinea pigs, rabbits, cats and dogs intraperitoneal injection of succinic acid can protect animals against hyperbaric oxygen, electroconvulsions and audiogenic convulsions. The anticonvulsant effect is related to the increase of GABA content in the brain. Hot plate method has analgesic effect, and pentobarbital has a synergistic effect, there are sedative and lower body temperature effect.
3. Anti-ulcer effect of rat pylorus ligation produces gastric ulcer, intraperitoneal injection or oral 50mg/kg, due to the inhibition of gastric juice secretion and dilation of the gastric muscle and was anti-ulcer effect.
4. The effect on immune function succinic acid dissolved in saline, add NaHCO₃ adjust pH to 6.4, the concentration of 11.8%, rats and rabbits daily intraperitoneal injection of 1mM (118mg)/kg, 2.5mM (295mg)/kg, 5mM (590mg)/kg, injected for 7d, once a day, the number of leukocytes in rats on the fourth day of use of the drug increased (P<0.025 years), but the number of white blood cells increased (P<1.025 years), the number of white blood cells increased (P<1.025 years), but the number of white blood cells increased (P<1.025 years). 0.025 yr), but the increase in phagocytosis was not significant. In rabbits, the leukocyte count also increased significantly at higher doses, and the phagocytosis rate also increased (P<0.01). In the specific skin reaction experiments in the intraperitoneal injection of succinic acid 5mg/kg, 48h for four consecutive times, or once a day for two weeks, the rabbits can be seen succinic acid can inhibit the passive and active skin allergic reactions, and can reduce the formation of serum IgE antibodies in animals.
5. Detoxification effect of succinic acid on poisonous cobra in mice have obvious protective effect, the rate of protection is similar to the original formula.

The natural source of succinic acid is the resin of pine plants buried in the ground for a long time into the amber, etc., in addition to a wide range of plants, animal tissues.
Succinic acid pine plant resin, buried in the ground for a long time into amber, amber contains 7.8% of this product. Angelica sinensis (Oliv.) Diels root of Umbelliferae, Pothos chinensis (Raf.) Merr. of Tennessee, Lesspedeza caneata G. Don of Leguminosae, Lobelia chinen-sis of Eustoma. Lour. whole grass, Orchidaceae plant grass coral (swollen knapweed) Sarcardra glabra (Thumb.) Nakai whole grass, Sandalwood spice plant thyme grass Thesium chinense Turcz. whole grass. Leguminosae alfalfa leaves; Umbelliferae angelica root; Tennessee vine orange; Eryngium; Orchidaceae; Sandalwood and strawberry. Grape etc.
 

There are many industrial preparation methods, mainly the following ones:
1. Oxidation method, paraffin wax by deep oxidation to generate a mixture of carboxylic acids, and then after steam distillation and crystallization and other separation steps can be obtained succinic acid.
2. Hydrogenation method, maleic anhydride or transbutyleneglycolic acid is hydrogenated under the action of catalyst to produce succinic acid, and then the finished product is obtained after separation. The catalyst is nickel or precious metal and the reaction temperature is about 130-140℃.
3. Acrylic acid carbonyl synthesis method, acrylic acid and carbon monoxide under the action of catalyst to produce succinic acid. Not yet industrialized.
4. Electrolytic oxidation method, phthalic anhydride and sulfuric acid and water in the ratio of 1:0.5:4, electrolysis in a ceramic electrolytic cell, can be obtained succinic acid. Electrolysis synthesis of raw materials for maleic acid or maleic anhydride, cathode and anode liquid with dilute sulfuric acid, separated by a cationic membrane, cathode and anode are generally used for lead plate, usually synthesized by plate and frame electrolysis tank.
5. Acetylene method, acetylene and carbon monoxide and water in the presence of [Co (CO) 4] catalyst, in the acidic medium reaction can be obtained succinic acid, the reaction temperature of 80-250 ℃, the pressure 2.94-49.03MPa.
6. Emerging fermentation method. Compared with traditional chemical methods, microbial fermentation method for the production of succinic acid has many advantages: competitive production costs; the use of renewable agricultural resources, including carbon dioxide, as raw materials, avoiding dependence on petrochemical feedstocks; and the reduction of environmental pollution caused by chemical synthesis processes.

Succinic acid is of low toxicity, with some irritation to the eyes, skin and mucous membranes, and no toxic effects on the whole body. Large oral doses can cause vomiting and diarrhea. The oral LD50 in rats is 8530 mg/kg. no occupational damage has been reported when used in industry. Be careful to wear protective equipment when handling or contacting succinic acid vapors to avoid coughing and skin irritation.

Environmental Hazards: Hazardous to the environment, may cause pollution to water and atmosphere.

Hazard of ignition and explosion: This product is flammable and irritating.

Hazardous Characteristics: Flammable when exposed to open flame and high heat. Powder and air can form explosive mixtures, when it reaches a certain concentration, it will explode when it meets sparks. Decomposed by high heat, releasing irritating fumes.

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